Strabane got the better of Bonds Glen in the Donegal sunshine at St Johnston.
Dharm Singh (3-4) and Stevie Dunn (2-26) had the Red Caps in all sorts of strife at 77 for seven before the Tyrone side rallied.
Ryan Gallagher (33) and Man-of-the-Match Mark McNulty - who hit a 15-ball unbeaten 25 - took Strabane to 117 for 7.
The chase never really got going as they were bogged down. Still, Divan Posthumus (28) gave them hope, but he fell to Andrew Mullen, with the left-arm spinner taking 3 for 8, just missing out on the M.O.M accolade.
Rhys Logue (2-6) also in the wickets as they retained the trophy won last year at home to Fox Lodge.
The Derry Midweek collected 500 euros and 105 pounds on their collection for charities around the ground.