Pakistan international Sami Aslam and New Zealander Corey Anderson are USA bound.
Aslam, who has scored seven fifties in 13 Tests, has become disillusioned with his treatment by PCB and is heading to play in San Francisco.
The 24 year-old has been a target for American organisers to boost both the profile of the sport and their playing strength.
He will have to wait three years before becoming eligible to represent the USA in the international ranks.
Also heading stateside is 29 year-old Anderson, who played 93 times for the Black caps in all formats.
He scored the second-fastest ODI hundred against West Indies back in 2014, but hasn't played for his country for two years, suffering a succession of injuries.
Anderson, who has played in the IPL, has signed a three-year deal with Major League Cricket.