Two times winners Rush have been handed a home draw against a strong Lisburn side in the game of the round.
The all-NW clash pits two former finalists as Killyclooney take on Drummond, while also in the region, Ballyspallen entertain Railway Union, while Glendermott host Knockharley.
Templepatrick have home advantage over St Johsnton - who won the Irish Cup back in 1987, while County Kerry play DLR County at The Oyster Oval.
Two NCU sides facing long journeys are Holywood who travel to County Galway, while Cregagh are on the road at Cregagh.
The matches take place on Sunday June 17, with the reserve date one week later.
NATIONAL CUP DRAW